筑波大学 University of Tsukuba 国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室 International Institute for Integrative Sleep Medicine (WPI-IIIS), Kutsumura・Saito Lab. 数理物質系化学域沓村研究室 Department of Chemistry, Faculty of Pure and Applied Sciences, Kutsumura Lab.

  • 筑波大学国際統合睡眠医科学研究機構
  • 独立行政法人 日本学術振興会
  • ムーンショット型研究開発事業

研究業績

2019 Original Papers / 2019 原著論文

  1. Yamada, D.; Yanagisawa, S.; Yoshizawa, K.; Yanagita, S.; Oka, J.; Nagase, H.; Saitoh, A.
    “Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice”
    Neuropharmacology 2019, 160, 107792. (web)
  2. Saitoh, T.; Seki, K.; Nakajima, R.; Yamamoto, N.; Kutsumura, N.; Nagumo, Y.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Tanimura, R.; Yanagisawa, M.; Nagase, H.
    “Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity”
    Bioorg. Med. Chem. Lett. 2019, 29, 2655-2658. (web)
  3. Kutsumura, N.; Inagaki, M.; Kiriseko, A.; Saito, T.
    “Total Synthesis of 3-epi-Juruenolide C”
    Chem. Pharm. Bull. 201967, 594-598. (web)
    selected as a Highlighted paper selected by Editor-in-Chief.
    selected as a Featured Article.

  4. Yamamoto, N.Ohrui, S.Okada, T.Saitoh, T.Kutsumura, N.Nagumo, Y.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Watanabe, Y.; Hayakawa, D.; Gouda, H.; Yanagisawa, M.; Nagase, H.
    “Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring”
    Bioorg. Med. Chem. 201927, 1747-1758. (web(Invited Paper)
  5. Yata, M.Kutsumura, N.Nagumo, Y.Yamamoto, N.Saitoh, T.; Ishikawa, Y.; Irukayama-Tomobe, Y.; Yanagisawa, M.; Nagase, H.
    “A Novel Rearrangement Reaction of Morphinan to Arylmorphan Skeletons and the Pharmacologies of Arylmorphan Derivatives”
    Heterocycles 201999, 134-144. (web(Invited Paper)
  6. Hirayama, S.; Obayashi, K.; Wada, N.; Ohyama, K.; Fuku, S.; Koyano, K.; Karaki, F.; Itoh, K.; Nagase, H.; Fujii, H.
    “The Practical Synthesis of Dissymmetrical 1,3,5-Trioxazatriquinane Derivatives Comprised of Three Distinct Carbonyl Compounds”
    Heterocycles 2019, 99, 1003-1019. (web(Invited Paper)
  7. Kutsumura, N.; Numata, K.; Mosaki, S.; Saito, T.
    “Total Synthesis of Haplacutines B and C”
    Heterocycles 201999, 614-624. (web(Invited Paper)
  8. Korkutata, M.; Saitoh, T.; Cherasse, Y.; Ioka, S.; Duo, F.; Qin, R.; Murakoshi, N.; Fujii, S.; Zhou, X.; Sugiyama, F.; Chen, J.-F.; Kumagai, H.; Nagase, H.; Lazarus, M.
    “Enhancing endogenous adenosine A2A receptor signaling induces slow-wave sleep without affecting body temperature and cardiovascular function”
    Neuropharmacol. 2019144, 122-132. (web)
  9. Sugiyama, A.; Yamada, M.; Furuie, H.; Gotoh, L.; Saitoh, A.; Nagase, H.; Oka, J.; Yamada, M.
    “Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats”
    J. Pharmacol. Sci. 2019139, 174-179. (web)
  10. Zhang, Y.Sugai, T.; Yamamoto, T.; Yamamoto, N.Kutsumura, N.; Nishiyama, S.; Einaga, Y.; Saitoh, T.Nagase, H.
    “Oxidative Cleavage of the Acyl-Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions”
    ChemElectroChem 2019, 6, 4194-4198. (web(Invited Paper)

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