筑波大学 University of Tsukuba 国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室 International Institute for Integrative Sleep Medicine (WPI-IIIS), Kutsumura・Saito Lab. 数理物質系化学域沓村研究室 Department of Chemistry, Faculty of Pure and Applied Sciences, Kutsumura Lab.

  • 筑波大学国際統合睡眠医科学研究機構
  • 独立行政法人 日本学術振興会
  • ムーンショット型研究開発事業

研究業績

2018 Original Papers / 2018 原著論文

  1. Kutsumura, N.; Kiriseko, A.; Niwa, K.; Saito, T.
    “Total Syntheses of 3-epi-Litsenolide D2 and Lincomolide A”
    J. Org. Chem. 201883, 11450-11457. (web)
  2. Sugiyama, A.; Yamada, M.; Siatoh, A.; Nagase, H.; Oka, J.; Yamada, M.
    “Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats”
    Psychopharmacol. 2018235, 2947-2955. (web)
  3. Saitoh, A.; Soda, A.; Kayashima, S.; Yoshizawa, K.; Oka, J.; Nagase, H.; Yamada, M.
    “A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice”
    J. Pharmacol. Sci. 2018138, 176-183. (web)
  4. Toyama, S.; Shimoyama, N.; Tagaito, Y.; Nagase, H.Saitoh, T.; Yanagisawa, M.; Shimoyama, M.
    “Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats”
    Anesthesiology 2018128, 992-1003. (web)
  5. Wang, Y.; Cao, L.; Lee, C.-Y.; Matsuo, T.; Wu, K.; Asher, G.; Tang, L.; Saitoh, T.; Russell, J.; Klewe-Nebenius, D.; Wang, L.; Soya, S.; Hasegawa, E.; Cherasse, Y.; Zhou, J.; Li, Y.; Wang, T.; Zhan, X.; Miyoshi, C.; Irukayama, Y.; Cao, J.; Meeks, J. P.; Gautron, L.; Wang, Z.; Sakurai, K.; Funato, H.; Sakurai, T.; Yanagisawa, M.; Nagase, H.; Kobayakawa, R.; Kobayakawa, K.; Beutler, B.; Liu, Q.
    “Large-scale forward genetics screening identifies Trapa1 as a chemosensor for predator odor-evoked innate fear behaviors”
    Nat. Commun. 20189(2041). (web)
  6. Ohshita, R.Kutsumura, N.Nagumo, Y.Yamamoto, N.Saitoh, T.; Hirayama, S, Fujii, H.; Nagase, H.
    “Synthesis of Novel 1,3-Dioxa-5-thiazatriquinane and 1-Oxa-3,5-dithiazatriquinane Derivatives and their Pharmacologies”
    Heterocycles 201897, 687-695. (web(Invited Paper)
  7. Kutsumura, N.Koyama, Y.Suzuki, Y.; Tominaga, K.; Yamamoto, N.Saitoh, T.Nagumo, Y.Nagase, H.
    “Favorskii-Type Rearrangement of the 4,5-Epoxymorphinan Skeleton”
    Org. Lett. 201820, 1559-1562. (web)
  8. Ohrui, S.Yamamoto, N.Saitoh, T.Kutsumura, N.Nagumo, Y.; Irukayama-Tomobe, Y.; Ogawa, Y.; Ishikawa, Y.; Watanabe, Y.; Hayakawa, D.; Gouda, H.; Yanagisawa, M.; Nagase, H.
    “Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity”
    Bioorg. Med. Chem. Lett. 201828, 774-777. (web)
  9. Saitoh, A.; Tominaga, H.; Ogawa, Y.; Irukayama-Tomobe, Y.; Yamada, M.; Yanagisawa, M.; Nagase, H.
    “Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice”
    Pharmacol. Rep. 201870, 350-354. (web)
  10. Tateno, K.; Ogawa, R.; Sakamoto, R.; Tsuchiya, M.; Kutsumura, N.; Otani, T.; Ono, K.; Kawai, H.; Saito, T.
    “Dibenzopyrrolo[1,2-a][1,8]naphthyridines: Synthesis and Structural Modification of Fluorescent L-Shaped Heteroarenes”
    J. Org. Chem. 201883, 690-702. (web)
  11. Kutsumura, N.Okada, T.; Imaide, S.; Fujii, H.; Nagase, H.
    “Acetic Anhydride-Mediated Retro-Ene Reaction via a [4.4.3]Propellane Skeleton Intermediate Containing a Quaternary Ammonium Linkage”
    Synthesis 201850, 4263-4269. (web(Invited Paper)
  12. Saitoh, A.; Suzuki, S.; Soda, A.; Ohashi, M.; Yamada, M.; Oka, J.; Nagase, H.; Yamada, M.
    “The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice”
    Behav. Brain Res. 2018336, 77-84. (web)

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