筑波大学 University of Tsukuba 国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室 International Institute for Integrative Sleep Medicine (WPI-IIIS), Kutsumura・Saito Lab. 数理物質系化学域沓村研究室 Department of Chemistry, Faculty of Pure and Applied Sciences, Kutsumura Lab.

  • 筑波大学国際統合睡眠医科学研究機構
  • 独立行政法人 日本学術振興会
  • ムーンショット型研究開発事業

Welcome!

筑波大学数理物質系化学域沓村グループ(製薬化学)/国際統合睡眠医科学研究機構(WPI-IIIS)沓村・斉藤研究室(創薬化学)では、オレキシン受容体やオピオイド受容体に作用する新規化合物を設計・合成し、睡眠と覚醒の制御や痛みや鬱の治療など、主に中枢神経系に作用する薬物を標的とした創薬研究を行っています。

Kutsumura/Saito Laboratory(Medicinal Chemistry Group)designs and synthesizes novel compounds that act on the orexin receptors and opioid receptors and conducts drug discovery research targeting drugs that act primarily on the central nervoussystem, such as controlling sleep and wakefulness and treating pain and depression.

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Oct. 22, 2024

The following presentation was made at The 14th CSJ Chemistry Festa.
Mizuki Oyanagi (M1): Synthetic Studies on Novel Environmentally Harmonious Sulfidizing Agents: Conversion Reaction from Amide to Thioamide

Oct. 11, 2024

The following presentations were made at The 53rd Congress of Heterocyclic Chemistry (Yamaguchi).
Yuta Koizumi (M1): Development of a novel synthetic route for KLF5 inhibitor NC114 derivatives
Tomoka Kazama (M1): Development of a comprehensive synthetic method for flavonoids and its application

Jul. 8, 2024


Mr. Kenshiro Nakamura received the Student Presentation Award from the 86th Symposium of The Society of Synthetic Organic Chemistry, Kanto Branch, Japan !
Kenshiro Nakamura (M1) : Structure-Activity Relationship Studies of Polysubstituted Phenol Derivatives Targeting Kinase Species

May 11, 2024

The following presentations were made at The 1st KOREA-JAPAN SYMPOSIUM on Chemistry with AI for Carbon Neutrality
Dr. Tomoya Sugai:
Development of Rapid Synthetic Method for 1,3,5-Trioxazatriquinane Skeleton by Using of Contnuous Flow System
Dr. Tsuyoshi Saitoh:
Development of remote-control drug toward spatio-temporal regulation of sleep

May 12, 2024

Master’s and Doctoral Program in Chemistry 2024 Open Campus

Apr. 30, 2024

“Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors”
K. Roy, X. Zhou, R. Otani, P-C. Y, S. Ioka, K. E. Vogt, T. Kondo, N. H. T. Frag, H. Ijiri, Z. Wu, Y. Chitose, M. Amezawa, D. S. Uygun, Y. Cherasse, H. Nagase, Y. Li, M. Yanagisawa, M. Abe, R. Basheer, Y-Q. Wang, T. Saitoh, M. Lazarus
Nat. Commun. 2024, 15, 3661. (web)

Apr. 24, 2024


The following students received the Best Student Presentation Award at the 144th Annual Meeting of the Pharmaceutical Society of Japan!
Yuta Koizumi (B4) : Development of a novel synthetic route for the KLF5 inhibitor NC114 derivatives
Tomoka Kazama (B4): Development of comprehensive synthetic method for flavonoids and structure-activity relationship study for salt-inducible kinases

Apr. 19, 2024

We held a Welcome BBQ for New Members.

Apr. 14, 2024

Is Kinase-Specific Drug Discovery Possible?
Tomoya Sugai & Noriki Kutsumura
Chemistry 2024, 79, 72-73. (web)

2024年4月1日

Fiscal year 2024 has started.

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